Hemmerling et al. [94] adopted a framework-based design method of get a novel class of indazole ether based molecular scaffolds and evaluated their glucocorticoid receptor (GR) modulate pursuits. The results indicated that numerous illustrations exhibited efficacy within a mobile transrepression assay at picomolar concentrations.Zhang et al. [eight
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Terbinafine works by inhibiting squalene epoxidase, the enzyme in fungal cells that convert squalene to squalene epoxide. This ends in an intracellular accumulation of squalene and leads to fungal cell Dying. Qin et al. [88] explained the synthesis of a novel series of aromatic carboxylic acid amides that contains 1H-indazole moiety based on the b
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